Poster Urometa

This AACR 2025 poster uses longitudinal single-nucleus RNA sequencing of metastatic urothelial cancer biopsies to understand why many patients stop responding to immune checkpoint inhibitors. It identifies baseline predictors of response and shows that resistance is linked to reduced antigen presentation and interferon signaling, increased T-cell exhaustion, and a shift toward pro-tumoral (M2-like) macrophages.