AACR Poster Landais

This AACR 2025 poster  combines single-nucleus RNA and epigenomic profiling from frozen ovarian cancer biopsies to map tumor cell states and track how they evolve under chemotherapy. It identifies 13 recurring tumor phenotypes, shows treatment reduces cycling cells but enriches TNFα/partial mesenchymal states, and links these patterns to survival—supporting single-nucleus profiling as a scalable way to monitor functional tumor heterogeneity in the clinic.